Israeli Scientists Track Moleculor Markers for Type II Diabetes

Israeli researchers have tracked down the early moleculor indicators that a person is at risk for developing Type II diabetes.

By Chana Ya'ar

Istraživači sa Hebrew univerziteta u Jeruzalemu su izolirali rane molekularne indikatore koji pokazuju da li je neka osoba rizična za razvoj dijabetesa tipa II. Dijabetes  je dijagnosticiuran u  oko pola milijuna osoba u Izraelu, i klasicifiran je u dva tipa.    

Istraživački tim u  univerzitetskom Institutu za medicinska istraživanja  Izrael/Kanada vodi dr. Assaf Hellman. Oni su razvili novu studiju sa više stupnjeva koja dozvoljava analizu epigenetskih varijacija koje doprinose razvoju bolesti.

Do sada je nedostajala direktna evidencija epigenetskih varijacija - to su mali molekularni markeri koji su vezani za strukturu DNA. Ti markeri karakteriziraju sumnju na dijabetes tipa II, kao i na druga bolesna stanja, rekli su istraživači. 

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In Hellman's study, researchers mapped the epigenetics of hundreds of patients with T2D (Type II Diabetes) and compared them with the epigenetics of healthy control subjects. Significant differences in the epigenetics were found in a large number of patients, making a clear distinction between those who were healthy, and those who were not.

"This method of mapping epigenetics allows a much more efficient prediction of risks to the disease in young people that have not yet showed any other symptoms of the disease," Hellman explained.

Researchers are hoping the discovery will contribute to the development of future medications and other ways to prevent T2D as well as other conditions, such as metabolic, autoimmune and psychiatric disorders.